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KMID : 0366220060410010051
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Korean Journal of Hematology
2006 Volume.41 No. 1 p.51 ~ p.55
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A Case of Steroid Refractory Acute GVHD Treated with IL-2 & TNF-αBlocker in a Myelodysplastic Syndrome Patient who Underwent Unrelated Allogeneic Stem Cell Transplantation
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Lee Hak-Hyun
Baek Yoo-Hum
Sohn Won
Lee Duk-Joo
Chang Myung-Hee
Choi Jung-Hye
Lee Young-Yeol
Kim In-Soon
Park Chan-Keum
Ahn Myung-Ju
Choi Chi-Un
Park Song-Ree
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Abstract
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Hematopoietic stem cell transplantation has evolved as a central treatment modality for the management of various hematologic malignancies. Despite adequate posttransplantation immunosuppressive therapy, acute GVHD remains a major cause of morbidity and mortality, even for the patients who have received HLA identical sibling grafts. Once established, acute GVHD is difficult to treat, and the best primary treatments such as corticosteroid have shown responses of approximately 50%. Once GVHD becomes steroid-refractory, the chances of survival are slim at best, and the possibility of long-term complications from chronic GVHD is almost always the rule. Many agents are currently being evaluated to treat this malady, including ATG, monoclonal antibodies, pentostatin, denileukin diftitox, etc. We reported here on a case of steroid refractory acute GVHD that was treated with IL-2 and TNF-α blocker in myelodysplastic syndrome patient who underwent unrelated allogeneic stem cell transplantation.
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KEYWORD
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Hematopoietic stem cell transplantation, Steroid-refractory acute GVHD, IL-2 blocker, TNF-α blocker
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